1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester, CAS 903550-26-5, is a boronic ester building block used primarily in synthetic organic chemistry and pharmaceutical intermediate development. Its key value is the combination of a protected pyrazole structure and a pinacol boronate group, which can support palladium-catalyzed cross-coupling and related research routes. I recommend buyers confirm identity, assay, water content, residual solvents, packaging, and batch documentation before placing a commercial order. At Maison Chemical, we support B2B customers with sourcing discussions, specification review, and quotation preparation based on project requirements.
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This guide is intended for pharmaceutical intermediate manufacturers, medicinal chemistry teams, process development groups, custom synthesis companies, and chemical distributors. It is also useful for purchasing managers who need to compare suppliers beyond a simple price-per-gram quotation. Because the compound may be used at different stages of discovery and process development, the correct purchase specification depends on the intended reaction, scale, and documentation requirements.
The molecule contains a pyrazole ring, a tetrahydropyran-2-yl substituent, and a boronic acid pinacol ester functionality. In practical synthesis, the boronate group is generally treated as a reactive handle for carbon-carbon bond formation, while the tetrahydropyranyl group can influence the compound’s protection profile, solubility, and downstream deprotection strategy. The exact reaction performance should be confirmed experimentally because solvent, catalyst, base, temperature, and substrate structure can all affect conversion.
Commercial and research references commonly associate CAS 903550-26-5 with the molecular formula C14H23BN2O3 and a relative molecular mass of approximately 278.16 g/mol. These identity details should be checked against the supplier’s current certificate of analysis and analytical data before use in a regulated or scale-up process. A CAS number is an important identifier, but it does not by itself define purity, packaging, stability, or suitability for a specific reaction.
For this product, “material options” usually refer to different commercial grades, package sizes, and documentation levels rather than fundamentally different chemical forms. A discovery project may accept a research-use batch with standard analytical documentation, while a process development project may require tighter controls on impurities, water, residual solvents, and batch-to-batch consistency. Buyers should avoid assuming that two products with the same CAS number have identical performance.
| Specification or document | Why it matters | Buyer action |
|---|---|---|
| Identity and CAS number | Confirms that the quoted material matches the requested intermediate. | Request the product name, CAS 903550-26-5, formula, and analytical identity. |
| Assay or purity | Helps estimate effective reagent quantity and impurity burden. | Confirm the test method and whether the value is chromatographic purity or assay. |
| Water and residual solvents | Boronate esters can be sensitive to storage and moisture exposure. | Ask for applicable test results and recommended handling conditions. |
| Analytical package | Supports incoming inspection and technical review. | Request available HPLC, NMR, LC-MS, or other relevant data before approval. |
| Packaging and storage | Protects the material during shipment and warehouse handling. | Confirm container type, net weight, sealing method, and storage guidance. |
A quoted purity percentage should always be interpreted together with the test method and specification definition. For example, HPLC area percentage is not automatically equivalent to absolute assay or purity by mass. I also recommend confirming whether the reported data apply to the exact batch offered, particularly when the material will enter a multi-step synthesis or a customer qualification program.
CAS 903550-26-5 may be considered when a synthesis requires a pyrazole-containing fragment with a boronate coupling handle. Its likely use cases include medicinal chemistry libraries, pharmaceutical intermediate routes, heterocyclic compound development, and custom synthesis programs. In Suzuki-Miyaura-type route design, the boronate ester may be evaluated as a coupling partner with a suitable aryl or heteroaryl halide, although actual compatibility must be established for each substrate and reaction system.
The product can also be useful during route scouting, where chemists compare several protected or functionalized pyrazole building blocks. The tetrahydropyranyl substituent may be relevant when the synthesis requires a particular N-substituted pyrazole architecture. However, I do not recommend selecting this material solely because it appears structurally similar to another boronate; substitution position, protection state, and impurity profile can materially change reaction behavior.
I suggest evaluating suppliers in five stages: identity confirmation, quality review, supply capability, commercial fit, and communication quality. First, compare the requested name and CAS number with the supplier’s product documentation. Next, review the available certificate of analysis, analytical methods, specification limits, and sample data rather than relying on a product page alone.
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Supply capability should be assessed according to the buyer’s real demand pattern. A supplier that can provide a small laboratory quantity may not be able to support repeat kilogram-level requirements, while a large-scale producer may not offer the documentation needed for early-stage screening. Ask about current stock, production route, standard package sizes, sample availability, lead-time assumptions, and the process for handling repeat orders.
Pricing for a specialty intermediate can vary with purity, batch size, analytical requirements, packaging, and requested delivery schedule. A low unit price may not represent the lowest total procurement cost if the buyer must pay for additional testing, repackaging, or an urgent shipment. When requesting a quotation, I recommend specifying the desired quantity, target specification, destination, documentation needs, and whether the order is for a sample, project batch, or recurring supply.
As planning examples, buyers may compare a 100 mg or 500 mg evaluation sample with larger project quantities, but these quantities should not be treated as standard availability unless confirmed by the supplier. Likewise, an estimated lead time of several working days for an in-stock material is not equivalent to a production lead time for a new batch. Maison Chemical can review these variables and provide a quotation based on the actual requirement rather than applying an unsupported fixed promise.
Buyers should be cautious about accepting undocumented claims such as “equivalent to pharmaceutical grade,” “guaranteed reaction performance,” or “always in stock.” Those statements require clear definitions and supporting records. A responsible supplier should distinguish between confirmed batch information, general product guidance, and an estimate that depends on production or logistics.
At Maison Chemical, I approach this product as a B2B sourcing project rather than a simple catalog transaction. We can discuss the requested quantity, target purity, analytical documentation, packaging, destination, and application stage before preparing a quotation. This helps align the proposed material with the buyer’s technical and commercial priorities.
Our support may include product identity review, specification comparison, sample or project-quantity discussions, documentation coordination, and export-oriented order communication. Availability, MOQ, lead time, and final commercial terms depend on the requested specification and current supply conditions, so I recommend confirming them in writing before purchase approval.
The best way to select CAS 903550-26-5 is to connect the chemical specification with the intended synthesis and procurement scale. Confirm the identity first, then evaluate batch-specific quality data, handling requirements, supply reliability, and total purchasing cost. This approach reduces the risk of receiving a material that matches the name but does not meet the project’s analytical or operational needs.
If you are sourcing 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester, send Maison Chemical your target quantity, required purity, destination, preferred packaging, and documentation expectations. We can then review the requirement and respond with relevant supply information, quotation details, and practical next steps for sample or commercial procurement.
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