3,5-Difluorophenylboronic acid, CAS 156545-07-2, is an aromatic boronic acid used primarily as a building block for carbon–carbon bond formation, especially in Suzuki–Miyaura coupling research and pharmaceutical intermediate synthesis. Its two fluorine substituents can influence the electronic properties, lipophilicity, and downstream reactivity of the aromatic ring. When I evaluate this material for a B2B project, I focus on identity, assay, impurity profile, packaging, documentation, and the intended reaction route rather than relying on the chemical name alone.
If you want to learn more, please visit our website.
This guide explains the compound’s basic properties, typical uses, selection criteria, purchasing considerations, and supplier evaluation points. It is intended for medicinal chemistry teams, process development groups, custom synthesis companies, research laboratories, and chemical distributors that need a practical sourcing framework.
I recommend this guide for buyers who are comparing suppliers of 3,5-difluorophenylboronic acid or deciding whether this building block is appropriate for a specific synthesis. It is also useful for procurement teams that need to request a quotation with clear technical and commercial specifications. The guidance applies to laboratory-scale purchasing as well as early process development, although larger-scale requirements should be reviewed separately.
Because specifications and availability can vary by supplier and production route, I treat published product information as a starting point. I confirm the final technical details through a current specification sheet, certificate of analysis, safety data sheet, and batch-specific documentation where applicable.
3,5-Difluorophenylboronic acid contains a boronic acid functional group attached to a difluorinated aromatic ring. The molecular formula is commonly represented as C6H5BF2O2, and the calculated molecular weight is approximately 157.91 g/mol. The structure contains 2 fluorine atoms at the 3- and 5-positions of the phenyl ring, which distinguishes it from unsubstituted phenylboronic acid and mono-fluorinated analogues.
The boronic acid group is valuable because it can participate in cross-coupling chemistry with suitable aryl or vinyl halides under appropriate catalytic and basic conditions. The exact reaction performance depends on the coupling partner, catalyst system, base, solvent, temperature, water content, and reaction work-up. I therefore avoid treating the chemical name as a guarantee of performance across every process.
| Item | Why It Matters |
|---|---|
| CAS number: 156545-07-2 | Helps confirm that the quoted material matches the requested compound. |
| Molecular formula and molecular weight | Supports structure confirmation, formulation calculations, and purchasing accuracy. |
| Assay or purity | Provides a basis for comparing batches and estimating the impact of impurities. |
| Water content and residual solvents | Can be important for moisture-sensitive reactions and process reproducibility. |
| Analytical data | HPLC, NMR, LC-MS, or other agreed methods can support identity and quality review. |
The most recognizable use of this compound is as an arylboronic acid partner in Suzuki–Miyaura coupling. In a suitable reaction system, the boronic acid can provide a difluorophenyl fragment for connection to an aryl, heteroaryl, or vinyl halide. This approach is widely used in medicinal chemistry because it allows researchers to assemble structurally diverse biaryl and related compounds from modular starting materials.
Actual conversion and selectivity must be established experimentally for each substrate combination. Potential factors include protodeboronation, catalyst compatibility, steric effects, base selection, and the stability of the coupling partner. For this reason, I recommend that buyers request practical handling information and test a representative batch before committing to a larger quantity.
Fluorinated aromatic fragments are frequently considered during the design of biologically active molecules because fluorine can alter molecular size, polarity, metabolic behavior, and binding interactions. 3,5-Difluorophenylboronic acid can serve as an intermediate for preparing more complex candidates, but its value depends on the target structure and route design. It should be viewed as a synthetic building block, not as an active pharmaceutical ingredient or finished formulation ingredient.
Academic and industrial laboratories may use this material in reaction screening, analogue generation, and route scouting. Custom synthesis providers may also use it when preparing small libraries or supplying intermediates for client programs. In these applications, consistent identity and reliable batch documentation are often more important than a low initial purchase price.
I begin by confirming the bond-forming reaction and the exact coupling partner. A buyer should identify whether the material is intended for a screening experiment, a medicinal chemistry campaign, analytical reference work, or process development. The required purity, package size, and documentation level may be different for each purpose.
I then define the minimum acceptable assay, analytical method, water specification, residual solvent limits, and packaging requirements. If the project is sensitive to boronic acid degradation or moisture, I ask the supplier to state recommended storage and handling conditions on the quotation or specification. A practical request should also clarify whether the quoted assay is area percentage, weight percentage, or another defined measurement.
With competitive price and timely delivery, Maison Chemical sincerely hope to be your supplier and partner.
Price should be compared together with package size, lead time, production status, shipping conditions, and documentation. A low unit price may not be advantageous if the material is only available in an unsuitable pack or if additional testing is required after receipt. For an early-stage project, I may start with a small evaluation quantity and then request a larger quotation after the batch passes internal testing.
When I assess a supplier, I look for clear product identification and a responsive technical contact. The supplier should be able to provide a current product specification, safety data sheet, and batch-specific certificate of analysis when available. I also ask whether the material is produced routinely, made to order, or sourced through a third party.
I do not recommend assuming a fixed market price or standard lead time for this product. These factors can change according to purity, quantity, batch availability, testing requirements, packaging, destination, and transportation restrictions. A supplier quotation should state the validity period, Incoterms where relevant, payment conditions, and whether analytical documents are included.
For small research quantities, availability from existing stock may be the main commercial advantage. For larger or repeat requirements, a planned production schedule may provide better continuity, but it can require a longer lead time. I encourage buyers to request both an evaluation quantity and a scale-up quotation so that technical and commercial decisions can be made together.
One common mistake is comparing products only by the CAS number and nominal purity. Two materials may share the same identity but differ in water content, residual solvents, particle form, packaging, or analytical documentation. These differences can affect reaction reproducibility and internal release procedures.
Another mistake is requesting a quotation without specifying the required quantity and quality standard. A clear inquiry should include the target pack size, preferred assay, destination, delivery schedule, documentation requirements, and whether a pre-shipment sample is needed. This allows the supplier to provide a more useful and comparable offer.
It is also important not to infer process suitability from a single successful small-scale experiment. I recommend confirming the reaction with the actual coupling partner and reviewing the isolated product, conversion, impurity profile, and work-up behavior before moving to a larger campaign.
At Maison Chemical, I approach 3,5-difluorophenylboronic acid sourcing as a technical procurement task rather than a simple product listing. I can help organize quotation details around CAS 156545-07-2, required quantity, target purity, packaging, documentation, and delivery expectations. Where project information is available, I can also help distinguish between an evaluation order and a repeat or scale-up requirement.
Our support can include specification review, document coordination, packaging discussions, and communication regarding MOQ and lead time. Any final specification, availability statement, and delivery commitment should be confirmed for the requested batch and destination before purchase. This approach helps buyers reduce ambiguity and create a more reliable sourcing record.
3,5-Difluorophenylboronic acid CAS 156545-07-2 is a fluorinated aromatic boronic acid building block, most commonly considered for Suzuki–Miyaura coupling and the preparation of more complex research intermediates. Its key identity references include the approximate molecular formula C6H5BF2O2 and molecular weight of 157.91 g/mol. Its practical suitability depends on the complete specification and the intended reaction, not only on the product name.
My recommended next step is to send a structured inquiry stating the required quantity, purity, destination, delivery target, packaging preference, and documentation needs. I can then help compare available options from Maison Chemical based on technical fit, commercial terms, and continuity requirements. For a quotation or sourcing discussion, provide your target quantity and project timeline so the most appropriate supply option can be reviewed.
For more 3,5-Difluorophenylboronic acid CAS 156545-07-2information, please contact us. We will provide professional answers.