Cat.No.
Product Name
Information
GC46008
(±)-Thalidomide-d4An internal standard for the quantification of (±)-thalidomide
GC62283
(S,R,S)-AHPC(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
GC38724
(S,R,S)-AHPC-propargyl(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs.
GC38055
BC-1215An inhibitor of FBXO3
GC66442
CC-17369CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC.
GC18862
CC-885CC-885 is a modulator of the E3 ligase protein cereblon with antiproliferative effects on human myeloid leukemia cell lines.
GC64851
CC-99282CC-99282 is a potent and orally active cereblon (CRBN) E3 ligase modulator (CELMoD). CC-99282 co-opts CRBN to induce potent and targeted degradation of Ikaros and Aiolos. CC-99282 can be used for researching non-Hodgkin lymphomas.
GC64835
CFT7455CFT7455 is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader. CFT7455 is an anti-cancer agent that binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM) (WO2022032132A1; Compound 1).
GC50364
cis VH 298Negative control for VH 298
GC62218
CRBN modulator-1CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.
GC32711
E3 ligase Ligand 1E3 ligase Ligand 1 (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1 can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
GC34291
E3 ligase Ligand 1 dihydrochlorideGC35924
E3 ligase Ligand 10E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC35925
E3 ligase Ligand 11E3 ligase Ligand 11 is the LCL161 derivative based IAP ligand. E3 ligase Ligand 11 can be connected to the ABL ligand for protein by a linker to form SNIPER.
GC35926
E3 ligase Ligand 12E3 ligase Ligand 12 is the LCL161 derivative based IAP ligand. E3 ligase Ligand 12 can be connected to the ABL ligand for protein by a linker to form SNIPER.
GC35927
E3 ligase Ligand 13E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC35928
E3 ligase Ligand 14E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC35929
E3 ligase Ligand 15E3 ligase Ligand 15 (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 15 can be connected to the ligand for protein by a linker to form PROTACs.
GC35930
E3 ligase Ligand 16E3 ligase Ligand 16 (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTAC.
GC35932
E3 ligase Ligand 18E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC33101
E3 ligase Ligand 1AE3 ligase Ligand 1A (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1A can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
GC32848
E3 ligase Ligand 2E3 ligase Ligand 2 (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 2 (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs.
GC30029
E3 ligase Ligand 3E3 ligase Ligand 3 (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein.
GC30164
E3 ligase Ligand 4E3 ligase Ligand 4 (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 4 (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
GC35933
E3 ligase Ligand 8E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC34566
E3 ligase Ligand 9E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC19195
IberdomideIberdomide (CC-220) is a cereblon modulator with an IC50 of 60 nM.
GC60963
KB02-COOHKB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 and KB02-SLF.
GC14976
Lenalidomide (CC-5013)An analog of thalidomide
GC13473
Lenalidomide hemihydrateTNF-α secretion inhibitor
GC14015
Lenalidomide hydrochlorideAn analog of thalidomide
GC62624
Lenalidomide-4-OHLenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.
GC63806
Lenalidomide-5-aminomethyl hydrochlorideLenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
GC62541
Lenalidomide-5-BrLenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC.
GC38579
Lenalidomide-BrLenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36.
GC62147
Lenalidomide-ILenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570.
GC60223
Lenalidomide-OHLenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620.
GC11697
Pomalidomide (CC-4047)An inhibitor of cereblon
GC19302
Protein degrader 1 hydrochloride(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. Protein degrader 1 hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
GC32433
Protein degrader 1 TFA(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. Protein degrader 1 TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
GC33068
TD-106TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
GC17054
ThalidomideAn immunomodulatory compound with diverse biological activities
GC60360
Thalidomide 5-fluorideThalidomide 5-fluoride is Thalidomide-based cereblon ligand?that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
GC63392
Thalidomide-5,6-FThalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
GC63810
Thalidomide-5-NH2-CH2-COOHThalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk).
GC60361
Thalidomide-5-OHThalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
GC62378
Thalidomide-NH-CH2-COOHThalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032.
GC60362
Thalidomide-O-C8-BocThalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs.
GC60363
Thalidomide-O-C8-COOHThalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.
GC38862
Thalidomide-propargylThalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs.
GC50623
VH 101, phenolVH 101, phenol is the VH032-based VHL ligand. VH 101, phenol can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4.
GC19375
VH-298VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology.
GC61452
VH032VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. VH032 is a VHL/HIF-1α interaction inhibitor with a Kd
GC65392
VH032 thiolVH032 thiol (VHL ligand 6) is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC.
GC34855
VL285VL285 is a potent VHL ligand with an IC50 of 0.34 μM.
GC64969
ZXH-1-161ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma.