3,5-Difluorophenol, identified by CAS 2713-34-0, is primarily used as a fluorinated aromatic building block and chemical intermediate. Its main value is the combination of a phenolic hydroxyl group and two fluorine substituents on a benzene ring, allowing chemists to incorporate controlled electronic and structural properties into downstream molecules. In B2B applications, I most commonly position it for pharmaceutical intermediate research, specialty chemical synthesis, agrochemical discovery, and advanced materials development rather than as a standalone end-use product.
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At Maison Chemical, we support buyers who need to evaluate this material for route development, laboratory synthesis, process scale-up, or recurring intermediate supply. The appropriate use depends on the buyer’s reaction pathway, required specification, impurity profile, quantity, and regulatory documentation. Because final applications vary, I recommend confirming the intended synthesis and quality requirements before selecting a commercial grade.
3,5-Difluorophenol contains a phenolic hydroxyl group that can participate in further chemical transformations. The hydroxyl group may serve as a functional handle for derivatization, while the fluorine atoms can influence the electronic character, polarity, lipophilicity, and metabolic behavior of a finished molecule. These features make the compound useful as a starting material when a synthesis requires a difluorinated aromatic structure.
The compound has the molecular formula C6H4F2O and a reported molecular weight of approximately 130.09 g/mol. Its identity is defined by the fluorine atoms at the 3 and 5 positions relative to the phenolic hydroxyl group. This positional arrangement matters because regioisomers can behave differently in substitution, coupling, protection, and downstream optimization reactions.
Fluorine substitution is widely used in medicinal and specialty chemistry to adjust molecular properties without substantially increasing molecular size. However, the effect of fluorine is molecule- and route-dependent, so it should not be treated as a guarantee of improved biological performance or process efficiency. In practical synthesis, the main benefit is that 3,5-Difluorophenol provides a defined aromatic fluorine pattern that can be carried into more complex target structures.
One important use is the preparation of fluorinated pharmaceutical intermediates. Research and process chemists may use 3,5-Difluorophenol as an input for the synthesis of substituted phenols, aryl ethers, heterocycle-linked compounds, and other aromatic building blocks. The compound is generally a starting or intermediate material, not a finished active pharmaceutical ingredient.
Its suitability for a specific pharmaceutical route depends on reaction compatibility, required regioselectivity, impurity control, and the downstream product’s regulatory pathway. Buyers should therefore assess it using route-specific data rather than assuming that a general catalog specification will automatically meet process requirements. Maison Chemical can help organize the relevant technical information for internal review and supplier qualification.
Fluorinated aromatic intermediates are also used in discovery and development programs for specialty chemicals and agrochemical candidates. In these programs, 3,5-Difluorophenol may be selected when a project requires a difluorinated phenolic fragment or a platform intermediate for preparing a series of analogues. The exact use is determined by the target structure and the chemistry selected by the customer’s development team.
For early-stage discovery, the ability to obtain a consistent building block can be more important than immediate large-volume demand. A reliable material identity, clear analytical documentation, and predictable packaging help laboratories compare reaction results across experiments. For later-stage programs, buyers typically require tighter control of batch-to-batch consistency, supply continuity, and change notification.
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Another potential use is research involving fluorinated aromatic materials, functional monomers, and specialty intermediates. The phenolic group can be modified to create derivatives with different reactivity or material properties. Whether the compound is suitable for a particular polymer, coating, electronic material, or functional molecule must be verified experimentally because performance depends on the complete formulation, not on this intermediate alone.
3,5-Difluorophenol is normally evaluated as a defined small-molecule intermediate rather than as a broad family of material grades. Differences between offers may relate to assay, water content, residual solvents, color, trace metals, packaging, and analytical method. A buyer should distinguish between a general research-grade requirement and a process-grade requirement before requesting quotations.
| Evaluation Item | Why It Matters |
|---|---|
| Identity and CAS number | Confirms that the supplied material matches CAS 2713-34-0 and the intended regioisomer. |
| Assay or purity | Helps determine whether the material is appropriate for screening, route development, or process work. |
| Water and residual solvents | May affect moisture-sensitive reactions, catalyst systems, and calculated reagent quantities. |
| Packaging and quantity | Supports safe handling, inventory planning, and scale-up from sample quantities to commercial orders. |
| Documentation | Allows quality, regulatory, and purchasing teams to review the material before approval. |
Purity targets should be agreed in advance rather than assumed. For example, a buyer may compare a 98.0% minimum specification with a 99.0% minimum specification depending on the reaction sensitivity and purification strategy, but the correct target must be supported by the customer’s process requirements and supplier documentation. I recommend requesting a current certificate of analysis, specification sheet, safety data sheet, and representative analytical information before placing a larger order.
The lowest quoted price is not always the lowest total procurement cost. A suitable supplier should be able to clarify material identity, available quantity, lead time, packaging, shipping conditions, and documentation before the purchase order is issued. These details are particularly important when a compound moves from laboratory testing to repeated manufacturing use.
Buyers should compare sample availability, minimum order quantity, production or replenishment lead time, and the supplier’s ability to support repeat orders. A small development request may involve 10 g to 100 g, while process evaluation may require kilogram-level planning; these quantities should be quoted according to current stock and production capacity rather than treated as guaranteed standard pack sizes. If the material is part of a multi-step route, supply continuity should be discussed early because an interruption can affect the entire development schedule.
Maison Chemical supplies 3,5-Difluorophenol CAS 2713-34-0 for customers evaluating pharmaceutical and specialty chemical applications. I can help organize a quotation around the requested quantity, specification, packaging, destination, and documentation needs. Where the application is still under development, our team can also review the buyer’s basic target requirements so that the commercial discussion is aligned with the intended use.
Our support is focused on practical B2B procurement: product identification, specification communication, document coordination, export planning, and repeat-supply discussions. We do not assume that one specification fits every synthesis, so the customer’s quality requirements should be confirmed before order acceptance. Availability, lead time, and commercial terms should likewise be confirmed for each inquiry.
In direct answer, 3,5-Difluorophenol CAS 2713-34-0 is used mainly as a synthesis intermediate for fluorinated pharmaceutical, agrochemical, specialty chemical, and research materials. It is valuable when a development route requires the specific 3,5-difluorophenol structure, but its final suitability must be demonstrated within the customer’s own chemistry and quality system.
The next practical step is to define the intended application, required purity, quantity, packaging, and documentation before comparing suppliers. Contact Maison Chemical with your target specification and estimated demand to request a tailored quotation and supply review for 3,5-Difluorophenol CAS 2713-34-0.
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