2-Bromopyridine-5-carbaldehyde, CAS 149806-06-4, is a brominated pyridine aldehyde used primarily as a synthetic building block for pharmaceutical research, agrochemical development, and specialty organic chemistry. Its two functional features—a bromine substituent and an aldehyde group on a pyridine ring—allow chemists to pursue different downstream transformations from one intermediate. I recommend evaluating this material through its identity, documented purity, analytical package, packaging, and supplier support rather than relying on the chemical name alone.
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For procurement teams, the most important starting data are the CAS number, molecular formula, calculated molecular weight, intended reaction, and required quality grade. The commonly assigned molecular formula is C6H4BrNO, with a calculated molecular weight of approximately 186.01 g/mol. Final purchasing decisions should be based on the supplier’s current specification, certificate of analysis, safety data sheet, and batch-specific analytical results.
This guide is intended for pharmaceutical intermediate buyers, process development chemists, medicinal chemistry teams, contract research organizations, and distributors sourcing 2-Bromopyridine-5-carbaldehyde. It is also useful for purchasing managers who need to compare suppliers before requesting samples or production quantities. I focus on practical B2B questions: what the compound is, where it fits in synthesis, which specifications matter, and how to reduce sourcing risk.
The guide is not a substitute for a laboratory risk assessment, reaction-specific process review, or regulatory evaluation. Handling, storage, transport, and use should follow the supplier’s SDS and the requirements of the receiving facility. Because specifications can vary by manufacturer and batch, I advise buyers to confirm every critical parameter before placing an order.
2-Bromopyridine-5-carbaldehyde is an aromatic heterocyclic aldehyde containing a six-membered pyridine ring, a bromine atom at the 2-position, and an aldehyde group at the 5-position. The aldehyde can participate in condensation and reductive transformations, while the aryl bromide can serve as a functional handle for further cross-coupling or substitution chemistry. This combination makes the intermediate useful when a synthesis requires both carbonyl reactivity and a selectively positioned halogen.
| Property | Reference information | Procurement relevance |
|---|---|---|
| Product name | 2-Bromopyridine-5-carbaldehyde | Confirm the name matches the structure and intended route |
| CAS number | 149806-06-4 | Use as a primary identity check during quotation and receiving |
| Molecular formula | C6H4BrNO | Useful for stoichiometric calculations and database matching |
| Calculated molecular weight | Approximately 186.01 g/mol | Supports molar conversion and reaction planning |
| Functional groups | Pyridine, aryl bromide, aldehyde | Helps match the intermediate to the planned chemistry |
The formula and calculated molecular weight are useful reference points, but they do not prove batch quality. I recommend confirming identity by appropriate analytical methods such as nuclear magnetic resonance, mass spectrometry, infrared spectroscopy, and chromatographic analysis where applicable. The exact analytical requirements should reflect the customer’s reaction sensitivity and internal quality system.
Buyers may encounter this product in research, development, or larger-scale intermediate supply channels. The commercial difference is often not a different chemical structure, but the agreed specification, packaging format, documentation level, and supply quantity. A research quantity may be appropriate for route screening, while a development or production program may require tighter controls, repeat-batch review, and a more formal change-notification process.
Purity should be defined using a stated analytical method rather than a vague “high purity” description. Ask whether the reported value is based on area percentage, assay, or another calculation, and request information about specified or unspecified impurities when they may affect the reaction. For aldehyde intermediates, buyers should also discuss degradation-related observations and the analytical approach used to monitor them.
The physical form, container type, net weight, and labeling should be confirmed before shipment. I do not recommend assuming a particular appearance, melting range, storage temperature, or shelf life unless those details are included in the current product specification or SDS. Packaging should protect the material from conditions identified by the supplier as potentially harmful and should support traceability from delivery through laboratory use.
In pharmaceutical research, 2-Bromopyridine-5-carbaldehyde may be selected as a starting material for building substituted pyridine structures. The aldehyde can support transformations such as imine or oxime formation, reductive amination, oxidation, and carbon–carbon bond-forming strategies, depending on the reaction design. The bromine substituent may provide a separate site for palladium-catalyzed or other coupling approaches, subject to the specific substrate and process conditions.
In medicinal chemistry, the compound can help introduce a pyridyl aldehyde motif into screening libraries or lead-optimization programs. In process chemistry, its value depends on reproducible quality, reaction performance, impurity control, and the ability to secure repeat supply. I advise chemists to evaluate the intermediate in the actual route rather than assuming that a catalog specification will automatically meet process requirements.
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Potential use in agrochemical and specialty chemical research should also be assessed case by case. The presence of both a heteroaromatic nitrogen and a reactive aldehyde may support the preparation of more complex functional molecules, but the suitability depends on the target structure, reaction sequence, and downstream purification strategy. The supplier should not be asked to validate an application without receiving the relevant technical requirements.
Start by matching the product name, CAS 149806-06-4, molecular formula, and molecular weight with the quotation and technical documents. Request a current SDS, product specification, and representative or batch-specific certificate of analysis. If the material is critical to a route, I also recommend asking whether additional structure-confirming data can be provided under the supplier’s documentation policy.
Do not request a price before defining the intended use and minimum acceptance criteria. A discovery project may prioritize fast sample availability, while a scale-up project may require impurity limits, consistent analytical methods, and controlled packaging. The purchase specification should identify the tests that determine acceptance, including identity, assay or purity, water or residual solvent limits when relevant, and appearance if it is meaningful for handling.
Compare minimum order quantity, sample policy, standard pack sizes, production capacity, lead time, and quotation validity. Lead time should be confirmed for the exact quantity and specification because a small laboratory sample and a larger manufacturing lot may follow different planning cycles. I also advise buyers to ask how the supplier handles out-of-specification material, batch reservations, documentation revisions, and changes in raw materials or manufacturing location.
A capable supplier should be able to answer practical questions without making unsupported claims. Maison Chemical can support B2B buyers by discussing target specifications, packaging needs, documentation expectations, and the intended application before quotation. When a project is still being developed, early communication helps determine whether the requested grade is realistic and whether a sample-to-production transition can be planned.
The price of 2-Bromopyridine-5-carbaldehyde is influenced by quantity, quality requirements, packaging, testing, production scheduling, and shipping destination. A lower unit price may not represent the lowest total procurement cost if it comes with insufficient documentation, an unsuitable pack size, or an uncertain replenishment schedule. I recommend comparing complete landed requirements rather than comparing only the quoted price per kilogram.
MOQ is normally a commercial and production variable, not a fixed property of the chemical. Buyers should state whether they need a screening sample, a development lot, or recurring supply, and should request separate quotations where appropriate. For planning, include time for document review, sample evaluation, purchasing approval, production, quality release, and transportation rather than treating the quoted manufacturing lead time as the entire project schedule.
A practical improvement is to create a one-page purchasing specification before contacting suppliers. Include the compound identity, target quantity, acceptable quality range, required documents, packaging preference, destination, and desired delivery window. This format makes quotations easier to compare and gives the supplier enough information to respond accurately.
The right supplier for 2-Bromopyridine-5-carbaldehyde is not simply the one offering the lowest initial price. I recommend selecting a partner that can confirm identity, provide transparent batch documentation, align the specification with your synthesis, and communicate clearly about quantity, packaging, lead time, and repeat supply. These factors directly affect whether the intermediate can move efficiently from laboratory evaluation to development or routine procurement.
As a Chemicals and pharmaceutical intermediates supplier, Maison Chemical can discuss your required quantity, target specification, documentation package, and delivery expectations for 2-Bromopyridine-5-carbaldehyde CAS 149806-06-4. Send the intended application, quantity range, destination, and quality requirements with your inquiry so we can prepare a more relevant commercial and technical response. A clear request at the beginning is the most effective next step toward sample evaluation and responsible sourcing.
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