4-Hydroxycyclohexanone ethylene acetal, identified by CAS 22428-87-1, is a protected cyclohexanone derivative used as a synthetic intermediate, particularly when a chemist needs to preserve a ketone-related carbonyl position while working with the hydroxyl functionality. I recommend evaluating this material through three connected factors: confirmed identity, application-specific quality requirements, and reliable bulk supply conditions. At Maison Chemical, I support buyers by reviewing technical specifications, documentation, packaging, and delivery requirements before quotation.
This guide explains what the compound is, where it may fit in pharmaceutical and fine-chemical synthesis, which specifications should be checked, and how to assess a supplier for laboratory, pilot, or production purchasing. Because commercial specifications can differ by manufacturing route and batch, buyers should treat the values below as purchasing guidance rather than an unsupported product certificate.
This guide is intended for pharmaceutical intermediate manufacturers, medicinal chemistry teams, process development groups, contract manufacturing organizations, and distributors sourcing CAS 22428-87-1. It is also useful for procurement professionals who need to compare suppliers beyond the lowest quoted price. The compound may be purchased for route development, scale-up evaluation, or use as a recurring intermediate in a multi-step synthesis.
I do not recommend selecting this material solely by name or CAS number. A correct CAS reference reduces identity confusion, but it does not by itself define acceptable assay, impurity limits, water content, or manufacturing documentation. The final specification should be matched to the buyer’s reaction conditions and quality system.
4-Hydroxycyclohexanone ethylene acetal is generally understood as a cyclohexanone derivative in which the ketone functionality has been protected with an ethylene glycol acetal, while a hydroxyl group remains available for further chemical transformation. This combination can be useful in synthetic planning because the protected ketone and free alcohol offer different reaction opportunities. In practical terms, the acetal can help reduce unwanted reaction at the carbonyl position during selected downstream steps.
The compound is commonly associated with the name 1,4-dioxaspiro[4.5]decan-8-ol, although naming conventions may vary between databases, suppliers, and internal documents. The molecular formula is commonly listed as C8H14O3, and the corresponding molecular weight is approximately 158.20 g/mol. I advise buyers to confirm the structural designation, formula, molecular weight, and analytical data together rather than relying on one database entry.
A commercial specification should normally identify the product by chemical name, CAS number, molecular formula, molecular weight, and a suitable analytical method. A buyer may also request HPLC, GC, NMR, or other appropriate data depending on the material’s volatility, purity profile, and intended use. The selected method should be capable of distinguishing the target compound from starting materials, regioisomers, over-reaction products, and process-related impurities.
For many development and manufacturing programs, buyers may request an assay target of 98% or higher. That figure should be treated as a possible purchasing requirement, not as a universal claim for every batch of CAS 22428-87-1. I help customers align the requested assay and impurity limits with their process rather than automatically applying one specification to every application.
Appearance, physical form, color, solubility behavior, water content, and residual solvent information can affect weighing, charging, reaction performance, and storage. The exact form should be confirmed from the current batch documentation because presentation and physical characteristics may vary with production and packaging conditions. Buyers should also request the SDS for hazard communication, handling, personal protection, and transport review.
Packaging should be selected according to the project stage. A development buyer may prefer a 1 kg pack for controlled evaluation, while a production purchaser may ask about 25 kg packaging or another agreed commercial configuration. These quantities are examples for quotation planning only; actual MOQ, container type, and available pack size must be confirmed with the supplier.
| Specification Area | What I Recommend Checking | Why It Matters |
|---|---|---|
| Identity | CAS 22428-87-1, chemical name, structure, and analytical confirmation | Reduces the risk of purchasing a similarly named intermediate |
| Assay and impurities | Assay method, major impurity limits, and chromatographic profile | Supports reaction consistency and downstream purification planning |
| Physical quality | Appearance, form, water content, and residual solvents | Helps control charging, storage, and process behavior |
| Documentation | COA, SDS, specification sheet, and batch traceability | Supports internal approval and quality review |
The primary value of this compound is its role as a building block or protected intermediate in multi-step organic synthesis. The protected cyclic ketone framework can be incorporated into routes where selective reactions are required at the hydroxyl group or elsewhere in the molecule. Its suitability depends on the reaction sequence, deprotection strategy, impurity tolerance, and the final product’s quality requirements.
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In pharmaceutical intermediate development, I recommend reviewing the complete route rather than evaluating this intermediate in isolation. A material that performs adequately in an early discovery route may require tighter impurity control, stronger documentation, or a revised packaging system during process scale-up. Route-specific testing can be especially important when downstream purification is difficult or when trace impurities affect later reactions.
For scale-up, buyers should examine not only assay but also lot consistency, supply continuity, production capacity, and change-control communication. The acetal functionality may be sensitive to strongly acidic or hydrolytic conditions, so the purchasing team should share relevant process information when asking for technical support. A supplier cannot responsibly recommend storage or process conditions without understanding the intended use and available stability data.
Start by documenting the intended reaction, expected consumption, acceptable impurity profile, and analytical method. Decide whether you need a research-grade material, a process-development grade, or a production-oriented specification. If the compound will enter a regulated manufacturing route, confirm documentation and traceability requirements before requesting a final quote.
Ask each supplier for a current specification sheet, representative COA, SDS, and available analytical data. Compare the test methods, not only the numerical limits, because two suppliers may report assay using different techniques. I also recommend checking whether the COA is batch-specific and whether the supplier can provide a retained sample or pre-shipment sample where appropriate.
Request pricing by quantity tier, MOQ, packaging format, lead time, payment terms, and shipping basis. A lower unit price may not represent better value if the MOQ is excessive, the lead time is uncertain, or additional testing is required after receipt. For recurring supply, ask how the supplier manages raw-material changes, batch release, and communication of specification revisions.
The price of CAS 22428-87-1 can vary according to order quantity, purity requirement, analytical testing, packaging, production scheduling, and shipping destination. I recommend requesting separate quotations for sample, pilot, and bulk quantities so that the commercial comparison reflects the actual purchasing plan. Buyers should also clarify whether analytical testing, special packaging, and export documentation are included in the quoted price.
MOQ and lead time should be confirmed in writing because they may differ between ready stock and made-to-order production. A supplier may be able to support a small evaluation pack while requiring a different production schedule for larger quantities. Before approving a vendor, I suggest confirming a realistic delivery window, packaging details, batch documentation, and the process for handling any quality discrepancy.
At Maison Chemical, I approach CAS 22428-87-1 sourcing as a technical and commercial project rather than a simple product transaction. I can help organize the required identity information, specification targets, packaging preferences, documentation needs, and delivery expectations before an order is finalized. This approach helps buyers identify gaps early and reduces avoidable delays during vendor qualification.
For a quotation, please share the required quantity, target assay or impurity limits, intended application, destination, preferred packaging, and timeline. I can then review the request for suitable supply conditions and clarify which documents or samples are available for evaluation. Where a requirement is not confirmed, I will recommend verification rather than making an unsupported assumption.
4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 is a useful protected cyclic intermediate when its structural features match the planned synthetic route. The right purchase decision depends on verified identity, application-appropriate quality, reliable documentation, and realistic bulk supply conditions—not on the chemical name alone. Buyers should begin with a defined specification and then compare suppliers using both technical and commercial criteria.
My recommended next step is to send Maison Chemical your target quantity, quality requirements, packaging preference, destination, and desired delivery schedule. I can help you assess the available specification, documentation, sampling process, MOQ, and lead time so that your team can make a qualified sourcing decision.
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