3-Fluorophenylboronic acid, CAS 768-35-4, is an aryl boronic acid used primarily as a synthetic building block in cross-coupling and related organic chemistry. Its molecular formula is C6H6BFO2, and its relative molecular mass is approximately 139.92 g/mol. I recommend evaluating this material through identity, assay, water content, residual solvent, packaging, documentation, and supply continuity rather than relying on the CAS number alone.
This guide is intended to help researchers, process chemists, purchasing teams, and chemical distributors assess the product for laboratory or manufacturing use. I explain what the material is, where it may fit, which specifications should be reviewed, and how to prepare a practical request for quotation. Because actual purity, appearance, packaging, and lead time can vary by grade and batch, final purchasing decisions should be based on current lot-specific documentation.
3-Fluorophenylboronic acid is an aryl boronic acid containing a fluorinated benzene ring and a boronic acid functional group. The “3-fluoro” designation indicates that the fluorine substituent and the boronic acid group occupy a meta relationship on the aromatic ring. The product is commonly considered an intermediate or building block rather than a finished active ingredient.
The boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or heteroaryl halides. Depending on the reaction design, the compound may help introduce a fluorinated aryl fragment into a more complex molecular structure. Its practical value therefore depends on reaction compatibility, substrate selection, process conditions, and the required downstream purity.
| Item | Information for Buyer Review |
|---|---|
| Product name | 3-Fluorophenylboronic acid |
| CAS Number | 768-35-4 |
| Molecular formula | C6H6BFO2 |
| Molecular mass | Approximately 139.92 g/mol |
| Product form | Typically supplied as a solid; confirm appearance and form with the supplier |
| Documentation | Request a current COA, SDS, specification sheet, and analytical information where applicable |
The table provides an identification framework, not a substitute for a batch release specification. In particular, buyers should confirm assay method, impurity limits, water content, residual solvents, and stability expectations for the intended application. If a project requires a defined assay such as 98% or higher, that requirement should be written into the RFQ and confirmed before order placement rather than assumed from a general product listing.
One important use is the preparation of biaryl compounds through Suzuki–Miyaura coupling. Medicinal chemistry teams may evaluate 3-Fluorophenylboronic acid when they need to introduce a meta-fluorinated phenyl group into a candidate structure. Fluorine substitution can influence molecular lipophilicity, metabolic behavior, conformation, and electronic properties, but the effect must be evaluated for each specific molecule.
The material may also be used in discovery chemistry, parallel synthesis, and route-screening work. At this stage, small quantities are often sufficient for reaction development, analytical confirmation, and preliminary structure–activity studies. Buyers should still consider whether the chosen grade is suitable for later scale-up, because a material that performs adequately in a small experiment may require tighter impurity control during process development.
Process chemists may use this building block while developing a reproducible route toward an advanced intermediate. The relevant questions include coupling conversion, selectivity, work-up behavior, boron-containing by-products, palladium removal, and isolation efficiency. These factors are process-dependent, so I advise treating supplier data as a starting point and confirming suitability in the buyer’s own reaction system.
Custom synthesis organizations and research laboratories may also procure the compound for client projects. In these cases, consistent lot documentation and reliable replenishment can be as important as the initial price. A supplier should be able to discuss the requested quantity, target specification, packaging, and document package before the buyer commits to a long-term supply plan.
For early discovery work, the main priorities may be confirmed identity, usable assay, acceptable appearance, and delivery speed. For process research, buyers commonly need more detailed impurity information, defined analytical methods, and evidence that successive lots can be compared. For regulated or tightly controlled programs, the customer may also require formal change notification, traceability, and additional quality documentation.
Maison Chemical are exported all over the world and different industries with quality first. Our belief is to provide our customers with more and better high value-added products. Let's create a better future together.
There is no single specification that is appropriate for every project. Before requesting a quotation, define the intended reaction, estimated annual demand, acceptable assay, water limit if relevant, packaging format, and required delivery location. This information allows Maison Chemical to assess the request more accurately and reduces the risk of comparing quotations that are based on different quality levels.
Buyers should state whether they need a screening quantity, a development quantity, or a manufacturing-support quantity. For example, an RFQ may request 1 g, 10 g, or 100 g for separate project stages, while larger requirements should be discussed as a planned supply program. These quantities are planning examples rather than a claim about standard stock sizes, so availability should be confirmed for each inquiry.
Packaging should protect the material from contamination and should be suitable for the expected storage and transportation conditions. The supplier should identify the net quantity, lot number, manufacturing or retest information where applicable, and recommended handling conditions. If the material will be stored for an extended period, the buyer should also request available stability or retest guidance rather than making assumptions from the product name.
3-Fluorophenylboronic acid should be handled according to its current SDS and the buyer’s chemical hygiene procedures. Personnel should use appropriate personal protective equipment, avoid generating dust, and work with suitable ventilation when opening or transferring the material. The SDS should be reviewed before use because hazard classification, recommended controls, and disposal requirements must be based on the supplied product and applicable regulations.
Storage conditions should follow the supplier’s label and SDS instructions. The container should remain properly closed and clearly identified when not in use, with exposure to contamination, moisture, and unsuitable temperatures minimized where relevant. Buyers should not infer a universal storage period or stability profile without checking the lot documentation and supplier recommendation.
The price of 3-Fluorophenylboronic acid can vary according to quantity, assay requirement, packaging, analytical documentation, production status, and shipping destination. A low unit price may not represent the best overall value if it excludes required testing or creates an extended replenishment risk. I recommend comparing the total procurement requirement rather than comparing only the per-gram figure.
MOQ and lead time should be confirmed in writing because they may differ between available stock and scheduled production. A buyer requiring urgent delivery should ask whether the quoted material is from an existing lot and whether the full document package is ready. A buyer planning recurring demand should provide a forecast so that the supplier can discuss production scheduling and possible supply continuity more realistically.
As a manufacturer, supplier, and exporter serving B2B chemical buyers, Maison Chemical can help organize an inquiry around product identity, target specification, quantity, destination, packaging, and documentation needs. Our role is to provide practical commercial and technical information for evaluation, while the customer remains responsible for confirming suitability in its own process and regulatory context. For qualified inquiries, a clear specification and forecast usually allow us to respond more efficiently than a request containing only the CAS number.
3-Fluorophenylboronic acid CAS 768-35-4 is a useful fluorinated aryl building block for research, medicinal chemistry, and process-development applications, particularly where a meta-fluorophenyl fragment is required. The most reliable procurement approach is to verify the molecular identity, approximately 139.92 g/mol molecular mass, agreed quality limits, lot documentation, packaging, and supply timing before purchase. Application testing should confirm that the material performs adequately in the buyer’s specific coupling or synthesis route.
My recommended next step is to send Maison Chemical the required quantity, target assay, application stage, destination country, packaging preference, and document requirements. We can then assess the appropriate supply option and provide quotation information subject to current availability and confirmation. This structured approach helps qualified B2B buyers reduce avoidable specification gaps and make a better-informed sourcing decision.
For more 3-Fluorophenylboronic acid CAS 768-35-4information, please contact us. We will provide professional answers.