When I evaluate 4-(N-Boc-amino)phenylboronic acid, CAS 380430-49-9 for a bulk procurement project, I focus on four points: identity, documented quality, application fit, and supply execution. This compound is an aryl boronic acid intermediate containing both a boronic acid group and a Boc-protected amino group, making it useful for palladium-catalyzed cross-coupling and subsequent amine deprotection workflows. Its commonly listed molecular formula is C11H16BNO4, with a molecular weight of approximately 237.06 g/mol. As a supplier, Maison Chemical helps buyers confirm these details before comparing quotations, quantities, documentation, and delivery requirements.
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I prepared this guide for pharmaceutical and fine chemical procurement teams, process chemists, contract development and manufacturing organizations, and distributors sourcing CAS 380430-49-9. It is also relevant to laboratories moving from milligram or gram-scale experimentation toward repeated kilogram-level purchasing. The objective is not simply to identify a low price, but to establish a reliable purchasing framework that reduces specification and delivery risk.
Buyers should use this guide when they need to compare suppliers, request a quotation, review a certificate of analysis, or prepare an internal material approval package. The exact requirements may differ between research use, process development, and regulated manufacturing. I therefore recommend confirming the intended use before requesting a final commercial offer.
4-(N-Boc-amino)phenylboronic acid is an aromatic boronic acid derivative with a para-substituted Boc-protected amino group. The boronic acid functionality is commonly used as a coupling handle in synthetic chemistry, while the Boc group temporarily protects the aniline nitrogen during selected reaction sequences. This combination allows chemists to introduce the substituted phenyl unit first and expose the amino group later when the route requires it.
The CAS number is 380430-49-9, and the commonly reported molecular formula is C11H16BNO4. The approximate molecular weight is 237.06 g/mol; buyers should still use the supplier’s current specification and analytical documentation as the controlling commercial reference. Physical appearance, assay, water content, residual solvents, and storage guidance should be verified from the lot-specific documentation rather than assumed from a catalog description.
For an initial supplier screen, I normally request the product name, CAS number, molecular formula, molecular weight, assay method, and an example or lot-specific certificate of analysis. The analytical method should be clearly identified, such as HPLC, NMR, or another method appropriate to the supplier’s quality system. A reported assay value is meaningful only when the test method, basis, and acceptance criteria are also clear.
Do not treat a product page alone as a complete quality package. For bulk procurement, I recommend confirming whether the quoted material is released against an internal specification, a customer specification, or a general commercial specification. If your process has a narrow impurity profile or a defined water limit, communicate those requirements before the supplier issues the final quotation.
A practical document package may include an SDS, certificate of analysis, product specification, packing information, and a statement of origin when required by your purchasing process. For regulated or quality-sensitive projects, you may also need a batch number, manufacturing date, retest or recommended re-evaluation information, and a declaration concerning residual solvents or elemental impurities. The availability of each document should be confirmed for the actual production lot.
The most common reason to select this intermediate is its dual synthetic utility. In a typical route, the boronic acid group can participate in a cross-coupling reaction with a suitable electrophilic partner, while the Boc group helps protect the amino functionality during that stage. After the desired carbon-carbon bond is formed, the protecting group may be removed under route-specific conditions.
This material may be appropriate for medicinal chemistry libraries, pharmaceutical intermediate development, and fine chemical synthesis where a para-aminophenyl building block is required. However, application suitability depends on the reaction system, impurity tolerance, scale, and downstream purification strategy. I advise process chemists to evaluate representative material in their own reaction before committing to a large volume.
Buyers should also distinguish between research-grade purchasing and manufacturing-grade procurement. A small laboratory order may prioritize immediate availability and flexible packaging, whereas a commercial process usually requires lot consistency, defined release testing, controlled packaging, and a documented replenishment plan. The same product name does not automatically mean that two suppliers offer equivalent quality systems or service levels.
Start by sending the supplier the complete identity: 4-(N-Boc-amino)phenylboronic acid, CAS 380430-49-9, and any internal material code. Ask the supplier to confirm the formula and approximate molecular weight shown in its commercial documentation. This step prevents confusion with similarly named aminophenylboronic acids, differently positioned isomers, or deprotected analogues.
State whether the material is for screening, process development, pilot production, or commercial manufacture. Then specify the requested package size, estimated annual demand, preferred delivery location, and whether you require one batch or multiple batches. I also recommend asking whether the supplier can support a sample, a development quantity, and a later bulk order without changing the agreed specification.
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A price comparison is useful only when the offers use the same assay basis, packaging assumptions, Incoterms, payment terms, and documentation scope. A lower unit price may not represent a lower total cost if additional testing, repacking, customs handling, or expedited freight is required. Ask each supplier to separate material cost, packaging cost, logistics cost, and any optional analytical charges.
For recurring supply, I look for a clear quality contact, traceable batch documentation, and a defined process for handling deviations or replacement requests. I also ask how the supplier manages production scheduling and whether the quoted lead time begins after payment, purchase order confirmation, or technical approval. These details are especially important when the intermediate is connected to a time-sensitive synthesis campaign.
Pricing for CAS 380430-49-9 can vary according to quantity, assay requirement, packaging, production route, testing scope, and shipping destination. Rather than relying on a single catalog price, buyers should request tiered quotations for sample, development, and bulk quantities. Minimum order quantity should be confirmed in writing because it may differ between available stock and new production.
Lead time should also be treated as a commercial variable, not a fixed property of the chemical. Stock availability, batch release, document review, production scheduling, and export arrangements can each affect the final delivery date. When requesting a quote, provide a target date and ask the supplier to state whether the material is available from existing inventory or requires manufacturing.
For planning purposes, I suggest maintaining at least 2–3 procurement scenarios: an immediate development quantity, a planned process-development quantity, and a larger replenishment quantity. This gives the buyer a better basis for comparing unit economics and supply continuity. These planning ranges are procurement examples, not a guaranteed MOQ or lead time for every order.
Before approving a supplier, I recommend using a written checklist rather than relying only on email impressions. The checklist should record identity confirmation, specification review, analytical documentation, packaging, shipping terms, lead time, payment conditions, and escalation contacts. It should also identify which requirements are mandatory and which are negotiable.
| Evaluation Area | Questions to Confirm |
|---|---|
| Identity | Does the supplier confirm CAS 380430-49-9, formula, and molecular weight? |
| Quality | Is a lot-specific COA available, and are the methods and limits stated? |
| Packaging | Is the container suitable for the quantity, transport route, and handling conditions? |
| Commercial terms | Are MOQ, price tiers, Incoterms, payment terms, and quotation validity clear? |
| Supply continuity | Can the supplier discuss repeat orders, batch planning, and change communication? |
One frequent mistake is ordering by a shortened name without confirming the CAS number and substitution position. Another is accepting a generic purity statement without reviewing the analytical method or impurity limits relevant to the process. Buyers can also overlook the difference between a sample quotation and a bulk quotation, particularly when packaging and freight are excluded from the displayed price.
A further mistake is requesting documents only after placing the order. If your organization requires an SDS review, supplier questionnaire, or quality approval, complete that review before the material is scheduled for shipment. Early technical communication usually makes it easier to identify acceptable alternatives, clarify exceptions, and avoid preventable delays.
At Maison Chemical, I approach this product as a B2B sourcing project rather than a simple catalog transaction. We can discuss the required quantity, intended application, target specification, packaging preference, destination, and documentation needs before preparing a commercial proposal. The exact availability, MOQ, lead time, and test package should be confirmed for each inquiry and production lot.
Our role is to help buyers organize the technical and commercial information needed for a responsible purchase decision. Where appropriate, we can support sample-to-bulk communication, quotation comparison, export coordination, and documentation review. I recommend sending your required quantity, delivery location, target date, and specification expectations so that our team can respond with a more relevant offer.
The best way to procure 4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9 is to combine chemical identity confirmation with a documented supplier-evaluation process. I recommend first defining your application and specification, then requesting a lot-specific COA, SDS, quotation, MOQ, packaging details, and delivery plan. After reviewing a representative sample or development batch, you can make a more defensible decision about bulk purchasing and repeat supply.
If you are evaluating Maison Chemical as a supplier, send us your required quantity, target specification, destination, preferred packaging, and requested delivery window. We will review the inquiry and confirm the available commercial and technical options for your project.
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