3,5-Dichlorophenylboronic acid is an aromatic boronic acid used primarily as a building block for carbon–carbon bond formation, especially in Suzuki–Miyaura coupling research and pharmaceutical, agrochemical, and materials chemistry. Its CAS number is 67492-50-6, and its molecular formula is commonly represented as C6H5BCl2O2. The calculated molecular weight is approximately 190.82 g/mol. I recommend confirming identity, assay, water content, residual solvents, and packaging requirements before placing a commercial order.
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3,5-Dichlorophenylboronic acid contains a phenyl ring bearing two chlorine substituents at the 3- and 5-positions and a boronic acid group attached to the ring. The boronic acid functionality is chemically valuable because it can participate in palladium-catalyzed cross-coupling reactions with suitable aryl or vinyl halides. The two chlorine atoms can also influence the electronic and steric properties of the aromatic intermediate.
For procurement purposes, I identify this product by its chemical name, CAS RN 67492-50-6, molecular formula, molecular weight, physical form, and batch-specific quality documentation. A CAS number supports chemical identification, but it does not by itself define grade, assay, particle size, packaging, or regulatory status. Buyers should therefore request a current specification sheet and certificate of analysis for the exact batch.
| Property | Information |
|---|---|
| Common name | 3,5-Dichlorophenylboronic acid |
| CAS Registry Number | 67492-50-6 |
| Approximate molecular formula | C6H5BCl2O2 |
| Approximate molecular weight | 190.82 g/mol |
| Functional group | Aryl boronic acid |
| Application category | Organic synthesis intermediate and coupling reagent |
PubChem provides a useful authoritative reference point for chemical identifiers, molecular structures, and related substance information. Because commercial records can differ in naming conventions and product specifications, I treat public databases as identity references rather than substitutes for a supplier’s batch documentation. Buyers can review the PubChem record for the substance and compare it with the supplier’s technical documents before approval.
Reference: U.S. National Library of Medicine PubChem.
The main function of 3,5-dichlorophenylboronic acid is to provide a 3,5-dichlorophenyl fragment in synthetic chemistry. Under appropriate reaction conditions, the boronic acid group can be converted through cross-coupling into a carbon–carbon bond with an aryl, heteroaryl, or vinyl partner. This makes the compound useful when a synthesis requires both a defined aromatic substitution pattern and a reactive boronic acid handle.
The chlorine substituents are not merely identification markers. They can alter the electron distribution, lipophilicity, steric environment, and downstream reactivity of the aromatic ring, although the practical effect depends on the reaction system and the final molecule. I recommend evaluating the compound within the complete synthetic route rather than assuming that every coupling protocol will provide the same yield or selectivity.
In a typical Suzuki–Miyaura transformation, an arylboronic acid reacts with an aryl or vinyl halide in the presence of a palladium catalyst, base, solvent, and controlled temperature. The precise conditions may vary substantially with catalyst loading, substrate structure, base selection, solvent, water content, and reaction scale. For this reason, a literature procedure should be treated as a starting point for process development, not as a guaranteed production recipe.
The compound may be especially relevant when a target molecule requires a chlorinated biaryl or heterobiaryl structure. However, chlorine atoms can remain in the product and may participate in later transformations, so route designers should determine whether the desired synthesis uses them as retained substituents or as additional handles for subsequent chemistry.
Medicinal chemistry teams may use 3,5-dichlorophenylboronic acid to introduce a chlorinated aryl group during analogue synthesis. Its defined substitution pattern can support structure–activity relationship studies, where researchers compare compounds with different halogenation or aromatic fragments. The material is generally considered a research or synthesis intermediate unless the buyer has separately established a validated manufacturing and regulatory pathway.
For discovery work, small package sizes, consistent analytical data, and rapid technical communication can be more important than a low unit price alone. I suggest confirming whether the supplier can provide an identity spectrum, assay method, chromatographic purity, and storage guidance for each lot used in a research program.
Chlorinated aromatic boronic acids may be used in the development of specialty molecules and agrochemical intermediates where a substituted biaryl or heteroaryl structure is required. The suitability of this compound depends on the target structure, reaction sequence, and impurity profile. It should not be selected solely because the name contains the required aromatic fragment; the boronic acid’s stability and compatibility with the process must also be assessed.
Researchers in organic materials and functional molecular design may evaluate this intermediate for preparing conjugated or aromatic compounds. In these applications, trace metals, colored impurities, water, and batch-to-batch variation can affect downstream reactions or material properties. I recommend defining critical quality attributes before scaling from milligram-level experimentation to gram or kilogram procurement.
The general cross-coupling principles underlying these uses are described in resources such as the Organic Syntheses collection and peer-reviewed synthetic chemistry literature. These sources explain reaction methodology, but they do not establish a universal specification or guaranteed performance for every commercial batch.
Reference: Organic Syntheses.
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Suppliers may offer this compound in different commercial formats even when the chemical identity is the same. The most important differences usually relate to purity target, analytical package, package size, moisture control, and intended use. I recommend comparing products by documented specifications rather than by grade labels alone, because terms such as “research grade” may not have identical meanings across suppliers.
Research-scale material is commonly selected for method screening, route scouting, and medicinal chemistry experiments. Buyers may prioritize package sizes such as 1 g, 5 g, or 25 g, depending on project needs. The relevant documents may include a specification sheet, certificate of analysis, safety data sheet, and basic chromatographic or spectroscopic information.
Process-development buyers generally require more than a small laboratory package. They may need quantities from 100 g to several kilograms, along with defined impurity limits, retest or shelf-life information, packaging controls, and a repeat-supply plan. At this stage, I recommend discussing analytical methods and sample approval before requesting a larger commercial quotation.
Some projects require a tailored purity target, a particular package configuration, or additional testing. A supplier may be able to review these requirements, but feasibility must be confirmed case by case. Customization should be documented through a written specification, approved sample, and agreed change-control process rather than relying on informal product descriptions.
For 3,5-dichlorophenylboronic acid, I normally recommend reviewing at least the following data points: assay, related substances, water content, residual solvents, appearance, identity, and packaging. The exact acceptance limits should be aligned with the buyer’s reaction and quality system. A single purity percentage is not enough to evaluate suitability for a sensitive synthetic route.
| Specification area | Why it matters | Buyer action |
|---|---|---|
| Assay or purity | Indicates the proportion of the intended chemical component | Request the batch result and test method |
| Related substances | May affect reaction selectivity and downstream purification | Review impurity limits relevant to the route |
| Water content | Boronic acids can be sensitive to moisture-related handling conditions | Ask whether a water test is included |
| Residual solvents | Can influence safety, processing, and regulatory evaluation | Request the solvent profile or applicable test statement |
| Identity | Confirms that the supplied material matches the specified compound | Request appropriate spectroscopic or chromatographic evidence |
| Packaging | Protects the material during storage and transportation | Confirm container type, net weight, and sealing method |
Storage and handling instructions should come from the product-specific safety data sheet and supplier documentation. The Globally Harmonized System provides a framework for communicating chemical hazards, but hazard classification must be based on the available substance data and the applicable jurisdiction. I advise buyers to review the SDS before shipment, especially when purchasing across national borders.
Reference: United Nations Globally Harmonized System of Classification and Labelling of Chemicals.
For early screening, a smaller package with reliable identity data may be sufficient. For process development, the buyer should place greater emphasis on impurity control, lot consistency, analytical method transfer, and supply continuity. The correct specification is therefore determined by the project stage, not simply by the highest advertised purity.
A low quoted price may not represent the lowest total procurement cost if the product lacks usable analytical data or requires repeated qualification. I recommend requesting a current certificate of analysis, SDS, technical specification, estimated lead time, and packaging details in the same inquiry. This allows the purchasing and technical teams to compare offers on a like-for-like basis.
Supply risk can arise from limited production capacity, inconsistent raw materials, long transit times, or unclear change-control practices. Buyers should ask whether the supplier supports repeat orders, pre-shipment documentation review, and communication of material changes. For critical routes, an approved backup source or safety stock policy may be appropriate.
At Maison Chemical, I support B2B buyers by organizing inquiries around chemical identity, required quantity, target specification, destination, application stage, and documentation needs. We can discuss research-scale supply, process-development quantities, packaging options, and the information needed for technical evaluation. Availability, lead time, and achievable specifications should be confirmed for the requested batch and destination.
For a more efficient quotation, I recommend sending the CAS number 67492-50-6, desired quantity in grams or kilograms, target purity, preferred packaging, delivery country, and requested documents. If the material will be used in a regulated or quality-controlled process, please also state whether you require a defined impurity profile, water testing, residual-solvent information, or a pre-approval sample. This helps us respond with a more relevant supply proposal rather than a generic price.
3,5-Dichlorophenylboronic acid CAS 67492-50-6 is a useful synthetic intermediate when a route requires a 3,5-dichlorinated aromatic fragment and a boronic acid coupling handle. Its approximate molecular weight is 190.82 g/mol, but molecular identity alone does not determine whether a particular batch is suitable for your process. I recommend confirming the specification, analytical package, storage instructions, and supply plan before purchase.
To request supplier information from Maison Chemical, prepare your required quantity, target purity, destination, packaging preference, and documentation list. We can then review the inquiry for suitable material options, estimated lead time, and commercial conditions. Contact us with the CAS number and project requirements so we can provide a focused B2B quotation for your 3,5-dichlorophenylboronic acid sourcing program.
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