4-(N-Boc-amino)phenylboronic acid, identified by CAS 380430-49-9, is a bifunctional aromatic boronic acid intermediate containing both a boronic acid group and a Boc-protected amino group. Its commonly reported molecular formula is C11H16BNO4, with a relative molecular mass of approximately 237.06 g/mol. I supply this material for research, process-development, and pharmaceutical-intermediate applications, subject to confirmed specification, batch availability, and intended-use requirements. Buyers should evaluate identity, assay, water content, residual solvents, packaging, documentation, and scale before placing a purchase order.
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The compound is particularly useful when a synthesis requires palladium-catalyzed cross-coupling through the aryl boronic acid while preserving the amino functionality in a protected form. The Boc group can later be removed under an appropriate deprotection process, allowing the product to serve as a controlled precursor to substituted aniline derivatives. For a reliable procurement decision, I recommend treating this material as a synthesis intermediate rather than as a finished active pharmaceutical ingredient or a universally standardized commodity.
This guide is intended for pharmaceutical and biotechnology companies, medicinal chemistry teams, contract research organizations, process-development laboratories, and chemical distributors evaluating CAS 380430-49-9. It is also relevant to procurement specialists who need to compare documentation, packaging, lead time, and technical support among suppliers. I focus on practical B2B decisions rather than presenting unverified claims about a particular batch or end-use product.
The most important question is not simply whether a supplier lists the CAS number. Buyers should confirm that the offered substance matches the required chemical identity, that the specification is suitable for the planned reaction, and that the supplier can provide traceable batch documentation. If the material will enter a regulated development pathway, the required documentation should be agreed before the first shipment.
4-(N-Boc-amino)phenylboronic acid contains two strategically useful functional groups on an aromatic ring. The boronic acid group participates in carbon–carbon bond-forming reactions, especially Suzuki–Miyaura coupling, while the N-Boc group temporarily protects the aniline nitrogen from unwanted reaction or coordination during synthesis. This combination allows chemists to introduce an aryl fragment first and reveal the amino group at a later stage.
The approximate molecular data are summarized below. The molecular formula and molecular mass should always be checked against the supplier’s current certificate of analysis and analytical data because commercial records can differ in naming conventions, hydration state descriptions, or reporting precision.
| Parameter | Reference value or description | Procurement relevance |
|---|---|---|
| Common name | 4-(N-Boc-amino)phenylboronic acid | Confirm the positional isomer and protected-group description |
| CAS Registry Number | 380430-49-9 | Use together with structure and analytical data for identity confirmation |
| Molecular formula | C11H16BNO4 | Useful for stoichiometry, analytical review, and inventory control |
| Approximate molecular mass | 237.06 g/mol | Used to calculate molar quantities and theoretical reaction input |
| Functional groups | Aryl boronic acid and Boc-protected aniline | Indicates potential coupling and later deprotection chemistry |
| Typical physical description | Solid intermediate; exact appearance should be batch-confirmed | Appearance alone is not sufficient for release or identity testing |
PubChem is a useful public reference for checking chemical names, structures, molecular formulae, and calculated molecular properties; however, it does not replace a batch-specific certificate of analysis. The National Center for Biotechnology Information provides the PubChem database as part of the U.S. National Library of Medicine, and I recommend using that record alongside supplier documentation during technical review. Source: PubChem, National Center for Biotechnology Information.
For an initial qualification, I recommend confirming the CAS number, chemical name, molecular formula, structure, and molecular mass as a consistent set of identifiers. A supplier should normally be able to discuss available identity data such as proton nuclear magnetic resonance, carbon nuclear magnetic resonance, infrared spectroscopy, or mass spectrometry, depending on the grade and purchase purpose. The exact analytical package should be agreed before ordering if the compound is intended for a regulated or late-stage process.
Because positional isomers and differently protected aniline derivatives can have similar descriptions, the structure should not be verified by CAS number alone. The buyer should compare the supplier’s product specification with the target structure and, where appropriate, review a representative spectrum. I can support this review by providing available technical documents for the quoted batch or production lot.
Assay is important, but it is not the only quality indicator for a boronic acid intermediate. Buyers should consider related substances, water content, residual solvents, inorganic residues, and the analytical method used for release. For a coupling reaction, trace impurities may affect catalyst performance, phase behavior, or downstream purification, so the acceptable limits should be linked to the actual process rather than copied from a generic catalog specification.
I do not recommend promising a universal purity level without reviewing the production lot and agreed specification. Instead, the purchasing document should state the required assay threshold, impurity limits, test methods, retest or expiry expectations, and packaging conditions. If the buyer has a validated internal method, sharing the method or acceptance criteria can reduce later disputes.
Organoboron intermediates should be handled according to the supplier’s safety data sheet and the buyer’s laboratory or plant procedures. The SDS should be reviewed for personal protective equipment, spill response, storage recommendations, and waste treatment before the material is received. I use conservative language for stability because actual performance depends on packaging, humidity, temperature history, and exposure to air or moisture.
Buyers should ask whether the offered product is supplied as a defined solid form and whether the supplier has a recommended storage range. A practical incoming-control plan may include visual inspection, container integrity, label verification, identity testing, and water or assay testing where required. A single appearance observation, such as “white to off-white solid,” should not be treated as proof of chemical conformity unless it is included in the approved specification.
The primary synthetic value of this compound is its aryl boronic acid functionality. In a Suzuki–Miyaura reaction, it may be evaluated as a coupling partner with a suitable aryl, heteroaryl, or vinyl electrophile under a catalyst and base system selected by the development chemist. The exact solvent, catalyst loading, temperature, reaction time, and work-up must be optimized for the substrate pair rather than assumed from the name of the intermediate.
The Suzuki–Miyaura reaction is widely recognized as a method for constructing carbon–carbon bonds from organoboron compounds and organic halides or related electrophiles. For foundational reaction information, buyers and chemists can consult the Nobel Prize background on palladium-catalyzed cross-coupling and authoritative organic chemistry literature. Source: Nobel Prize, 2010 Chemistry background on palladium-catalyzed cross-coupling.
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The Boc-protected amino group provides a route to control the reactivity of the aniline nitrogen during earlier synthetic steps. After the desired carbon–carbon bond is formed, the protecting group may be removed using a process compatible with the complete molecule. Deprotection conditions should be selected through laboratory development because acid sensitivity, solvent compatibility, and the stability of other functional groups can vary considerably.
This intermediate can therefore be relevant to the preparation of substituted anilines, heteroaromatic building blocks, medicinal chemistry libraries, and pharmaceutical intermediate candidates. I describe these as potential applications, not guaranteed outcomes, because suitability depends on the target structure, reaction sequence, scale, and quality requirements. A small-scale feasibility experiment is advisable before a large-volume commitment.
I recommend beginning with a written technical questionnaire covering identity, formula, molecular mass, assay, related substances, water, residual solvents, analytical methods, storage, packaging, and batch size. The supplier should also clarify whether the quoted material is manufactured in-house, sourced from a partner, or distributed under a resale arrangement. This distinction affects change control, communication speed, and the availability of production records.
For process development, the buyer should ask for a representative certificate of analysis and, when appropriate, supporting spectra. For regulated programs, additional expectations may include change-notification procedures, traceability, supplier questionnaires, and documentation for raw-material controls. I can review these requirements with the customer before quotation so that the proposed supply route is aligned with the project stage.
Pricing for CAS 380430-49-9 may vary with requested quantity, assay, packaging, production route, testing package, and delivery destination. A small research pack, a kilogram-scale development order, and a recurring commercial requirement should not be evaluated using the same price assumptions. Buyers should request a formal quotation that states quantity, unit, packaging, Incoterms, payment terms, document package, and quotation validity.
Minimum order quantity and lead time should be confirmed for each order rather than inferred from an online listing. For planning purposes, I suggest asking for at least 3 commercial scenarios: sample or evaluation quantity, development quantity, and repeat-order quantity. This approach helps identify whether a supplier can support scale-up without forcing the buyer to purchase more material than the project currently requires.
Delivery planning should also consider export documentation, dangerous-goods classification if applicable, customs requirements, and transit exposure. The number of days quoted as lead time should be defined clearly as either stock dispatch time or manufacturing time. If the material is time-sensitive for a campaign, I recommend reserving production capacity only after the specification and release documentation are approved.
A CAS number is an important identifier, but it does not independently confirm the quality of a specific shipment. The buyer should match the CAS number with the structure, formula, analytical data, and batch certificate. This is especially important when a company manages several protected aniline or phenylboronic acid derivatives with similar names.
A material that is acceptable for exploratory medicinal chemistry may not meet the impurity or documentation requirements of a process-development route. Buyers should explain whether the compound will be used for screening, route scouting, scale-up, registration-supporting work, or commercial manufacture. The supplier can then propose a more appropriate specification and document package.
“High purity” is not a sufficiently precise procurement requirement. The purchase specification should identify the analytical method, reporting basis, relevant related substances, and acceptance limits. If HPLC, GC, Karl Fischer, NMR, or another method is required, the method and sample-handling expectations should be discussed before release.
At Maison Chemical, I support customers evaluating 4-(N-Boc-amino)phenylboronic acid as a pharmaceutical intermediate or research chemical. My role is to connect the requested application with an appropriate specification, quantity, packaging format, analytical document set, and delivery plan. I do not treat an online product description as a substitute for batch-specific technical review.
Depending on project requirements and availability, I can discuss sample quantities, repeat supply, custom packaging, export documentation, and coordination of quality questions. For a new inquiry, please provide the required quantity, destination country, target specification, intended application, preferred delivery date, and whether a certificate of analysis or additional analytical data is required. These details allow me to prepare a more realistic B2B quotation.
4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9 is a useful bifunctional building block for synthetic routes that require an aryl boronic acid coupling handle and a temporarily protected aniline group. Its commonly reported formula is C11H16BNO4, and its approximate molecular mass is 237.06 g/mol. The strongest procurement decision combines chemical identity, batch-specific analytical evidence, application fit, documentation, MOQ, lead time, and supply continuity.
My recommended next step is to send Maison Chemical your required quantity, target specification, destination, application stage, and preferred delivery schedule. I can then help assess the appropriate supply format and clarify which documents are available for the proposed batch. Before committing to scale, buyers should complete a representative-sample evaluation and confirm that the material performs acceptably in their own validated or development process.
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