4-Chlorophenylboronic acid, identified by CAS No. 1679-18-1, is an aromatic boronic acid used mainly as a synthetic building block in pharmaceutical, agrochemical, and fine-chemical research. Its molecular formula is C6H6BClO2, and its reported molecular weight is approximately 156.37 g/mol. The molecule contains a boronic acid group and a chlorine-substituted phenyl ring, with the chlorine positioned at the 4-position relative to the boronic acid group. In practical terms, buyers typically evaluate this material by identity, assay, impurity profile, packaging, documentation, and supply consistency rather than by CAS number alone.
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4-Chlorophenylboronic acid is a para-substituted arylboronic acid. The “4-chloro” designation indicates that the chlorine atom and boronic acid group occupy opposite positions on the benzene ring. This structure gives the compound two useful features: an aryl chloride substituent that can remain available for further chemistry, and a boronic acid group that can participate in carbon–carbon bond-forming reactions.
Its CAS number is 1679-18-1, while its molecular formula is C6H6BClO2. The approximate molecular weight is 156.37 g/mol, which is useful for stoichiometric calculations, solution preparation, and analytical method development. PubChem provides a recognized public reference for the compound’s chemical identity and structure; buyers should still confirm the exact product specification against the supplier’s current certificate of analysis.
The principal synthetic role of 4-chlorophenylboronic acid is as an arylboronic acid reagent in palladium-catalyzed cross-coupling, especially Suzuki–Miyaura-type reactions. In a typical application, the boronic acid functionality reacts with a suitable aryl or vinyl halide under an appropriate catalyst, base, solvent, and temperature system. The exact conversion depends on the reaction substrate, catalyst loading, water content, base selection, and process conditions, so the reagent should not be treated as a guaranteed solution for every coupling system.
The chlorine substituent can provide additional synthetic flexibility because it may remain intact during a selective transformation. Whether the aryl chloride is preserved or subsequently functionalized depends on catalyst choice, reaction order, and the relative reactivity of the available leaving groups. For process development, I recommend screening the reaction with a small, controlled quantity before making a larger procurement commitment.
These applications describe common synthetic roles rather than guaranteed performance in a specific route. Reaction success must be demonstrated using the buyer’s own substrate, analytical method, and process conditions. For regulated pharmaceutical work, the material should also be assessed within the buyer’s quality and change-control system.
Commercially, the same CAS number may be offered in different grades, package sizes, and documentation formats. A research-grade product may be suitable for discovery chemistry, while a process-development or manufacturing program may require tighter control of assay, water, residual solvents, metals, particle characteristics, and batch-to-batch variation. The correct choice therefore depends on the intended use rather than on the chemical name alone.
Grade names are not standardized across all suppliers. I recommend requesting the actual specification sheet and certificate of analysis instead of relying only on labels such as “high purity” or “technical grade.”
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| Item | Reference or Buyer Question | Why It Matters |
|---|---|---|
| CAS number | 1679-18-1 | Confirms the intended chemical identity. |
| Molecular formula | C6H6BClO2 | Supports formula verification and analytical calculations. |
| Molecular weight | Approximately 156.37 g/mol | Used for weighing, molarity, and reaction stoichiometry. |
| Assay | Confirm the supplier’s stated percentage and method | Influences effective reagent quantity and reaction reproducibility. |
| Water content | Request a value in % or ppm when moisture is process-critical | Boronic acids and coupling systems can be sensitive to process conditions. |
| Packaging | Compare requested quantities, such as 25 g, 100 g, or 1 kg | Helps control handling, storage, and total landed cost. |
PubChem lists the core identity information for 4-chlorophenylboronic acid, including its chemical formula and molecular weight. For safety classification, handling instructions, and storage conditions, I advise using the current SDS supplied for the specific batch and jurisdiction because those documents are product- and market-dependent.
Before placing an order, I recommend confirming the CAS number, molecular formula, molecular weight, appearance, assay method, and relevant impurity limits. Buyers may also request HPLC, GC, NMR, water, residual-solvent, or metal data when those tests are relevant to the synthesis. The appropriate analytical package should match the risk level of the project and the customer’s internal quality requirements.
A low unit price does not necessarily represent the lowest procurement cost if the material requires repeated qualification or creates delays in a time-sensitive route. Ask whether the supplier can provide a representative sample, a batch-specific COA, SDS documentation, consistent packaging, and a realistic lead-time estimate. For recurring demand, I also recommend discussing forecast volumes, preferred delivery frequency, and change-notification expectations before approval.
Storage should follow the supplier’s SDS and label instructions. Buyers should pay attention to moisture exposure, container integrity, temperature requirements, light exposure, and the time between opening and use. Do not assume that one storage range, such as 2–8°C, is suitable for every commercial presentation unless it is stated in the product documentation.
At Maison Chemical, we support buyers evaluating 4-chlorophenylboronic acid CAS 1679-18-1 for research, intermediate synthesis, and process-development applications. I can help organize the technical information needed for a quotation, including target quantity, required grade, packaging, delivery location, documentation, and any project-specific specification. Where appropriate, we can discuss sample evaluation and batch documentation before a larger supply decision.
Our role is to connect the chemical identity with the buyer’s actual procurement requirements. Instead of making unsupported claims about universal purity, fixed lead times, or guaranteed reaction results, we recommend confirming each requirement against the available batch, testing method, and delivery plan. This approach helps reduce misunderstandings between laboratory users, purchasing teams, quality departments, and manufacturing sites.
4-Chlorophenylboronic acid CAS 1679-18-1 is a chlorinated arylboronic acid with the formula C6H6BClO2 and an approximate molecular weight of 156.37 g/mol. Its main value is as a versatile aromatic building block, particularly for Suzuki–Miyaura-type cross-coupling and related synthetic research. The best product choice depends on the required assay, impurity profile, documentation, package size, storage instructions, and supply schedule.
As a next step, prepare your target quantity, application, desired specification, package requirement, destination, and documentation list. I can then help you evaluate the suitable supply option from Maison Chemical and identify which quality data should be reviewed before approval. For a quotation or technical discussion, contact Maison Chemical with your CAS number, estimated demand, and project timeline.
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